Abstract

Six adult dogs were used in an experimental model of osteoarthritis (OA) reproduced by intra-articular injection of sodium monoiodoacetate (MIA) in the left stifle joints. Contralateral joints served as control. Before the first MIA administration and at days 30, 60 and 105, synovial fluid samples were obtained aseptically from both joints to determine some physical (volume, colour, transparency, viscosity) and biochemical parameters (total protein, glucose, lactate dehydrogenase). The results showed that the used chemical model of OA reproduced successfully the dynamics of the disease in dogs. The changes in studied biochemical parameters (substantially decreased viscosity and glucose content and statistically significantly higher total protein content and lactate dehydrogenase (LDH) activities) corresponded with the severity of the process. A statistically significant negative correlation was observed between synovial fluid viscosity and its protein content and LDH activity (r = −0.77; p < 0.001).

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