Abstract
To assess the relationship between sodium intake and hypertension risk in cohort studies, based on a systematic review up to January 21, 2022, that also employed a dose-response meta-analysis. Dose-response analysis of available cohort studies (n = 11), using a dietary intake or urinary sodium excretion of 2g/day as the reference category, showed an excess risk starting at 3g/day. However, we found a linear relationship across the entire range of sodium exposure in an analysis restricted to studies that used 24h urinary sodium excretion information and had a low risk of bias. This review confirms prior findings based on experimental studies and identified an almost linear relationship between sodium intake/excretion and hypertension risk in cohort studies, reinforcing the validity of recommendations to prevent cardiovascular disease through the reduction of sodium intake in both normotensive and hypertensive adults.
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