Abstract
Background Insight of physiological processes and cellular metabolism makes 23Na-MRI conceptually appealing as non-invasive imaging discipline. Several studies report the applicability of 23Na-MRI for the detection and assessment of acute and chronic heart disease due to increased sodium concentration after myocardial infarctions. Bi-exponential decay of the signal and a low SNR compared to 1H-MRI makes 23Na-MRI unattractive for clinical use. With a high SNR and fast imaging technologies ultrahigh field MRI brings 23Na-MRI back into focus, asking for dedicated radiofrequency (RF) technology.
Highlights
Insight of physiological processes and cellular metabolism makes 23Na-MRI conceptually appealing as non-invasive imaging discipline
The volunteers were positioned prone to reduce artifacts due to respiratory motion. 23Na localizer imaging was performed with untriggered gradient echo (2D FLASH) imaging (FOV 320x380, TE=2,28 ms, TR=5,6 ms; TA=1,32 min; matrix size 5x5x40 mm, averages 256)
In vivo studies yielded a rather uniform signal intensity across the heart leading to adequate image quality
Summary
Insight of physiological processes and cellular metabolism makes 23Na-MRI conceptually appealing as non-invasive imaging discipline. Several studies report the applicability of 23Na-MRI for the detection and assessment of acute and chronic heart disease due to increased sodium concentration after myocardial infarctions. Bi-exponential decay of the signal and a low SNR compared to 1H-MRI makes 23Na-MRI unattractive for clinical use. With a high SNR and fast imaging technologies ultrahigh field MRI brings 23Na-MRI back into focus, asking for dedicated radiofrequency (RF) technology
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