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Abstract
Sodium hypochlorite (NaOCl) is routinely used as an endodontic irrigant to clean and disinfect the root canal system. Although it is generally believed safety, the tissue toxicity of NaOCl cannot be ignored. This report describes two cases of accidental extrusion of sodium hypochlorite solution into the periradicular tissues during root canal instrumentation. The literatures were reviewed to explore possible etiologies and possible complications. Diagnostic criteria for sodium hypochlorite accidents and strategies to mitigate the risk are also suggested.
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