Abstract
Sodium fusidate (fusidic acid) is an antimicrobial agent used to treat methicillin-resistant Staphylococcus aureus infections. Several case reports have described drug interactions between sodium fusidate and CYP3A4 metabolised statins, leading to statin myotoxicity, including fatal myotoxicity. The mechanism of this interaction is unknown. We investigated the effects of sodium fusidate on recombinant CYP3A4 in vitro and found it to be a timedependent inhibitor of this enzyme at concentrations likely to be achieved with clinical dosing regimens. This finding may help to explain the mechanism of the apparent statin-fusidate interaction.
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