Abstract
By the mid 1960s, pioneering work using high-resolution electron microscopy, new fixation methods, and negative staining of isolated liver plasma membranes allowed the identification of a geometric subunit pattern likely associated with junctional domains (,). Furthermore, the application of tissue impregnation with electron-dense tracers revealed that the minute “gap” (2 nm wide) between the closely adjoining junctional membranes comprised an hexagonal subunit pattern. This type of membrane-membrane interaction, distinct from tight junctions, adhesion plaques, and desmosomes, was originally called “gap junction” (.
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