Abstract
To the Editor:— You have quoted comments on sodium chloride as a possible factor in heart disease ( JAMA 177 :115 [July 15] 1961) based on the work of Talbott et al. ( Ann Intern Med 54 :257 [Feb.] 1961). We have been working in this ... neglected... area for some years. We first reported disturbed lipid metabolism in rats eating excess sodium chloride in 1953, ( J Exp Med 98 :71 [July]) and later ( Amer J Med 16 :599 [April] 1954, and Ibid. 25 :713 [Nov.] 1958) in considerably more detail. In brief, there are numerous evidences of disturbed lipid metabolism in rats eating excessive sodium chloride; the most clearly defined is an elevation of serum cholesterol that is roughly proportional to the level of salt in the diet but is more closely correlated with the level of blood pressure. The experience of one of us (L. K. D.) is somewhat different ( J
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