Abstract

Voltage-gated sodium channels and pain associated with nerve injury and neuropathies.- Current approaches for the discovery of novel NaV channel inhibitors for the treatment of brain disorders.- Voltage-gated sodium channels and visceral pain.- The functional interaction of accessory proteins and voltage-gated sodium channels.- Sodium channels and nociceptive nerve endings.- Signalling cascades that modulate the activity of sodium channels in sensory neurons.- NaV1.8 as a drug target for pain.- Role of voltage-gated sodium channels in oral and craniofacial pain.- Sodium channel gating and drug blockade.- Future directions in sodium channel research.

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