Abstract
An efficient, straightforward and rapid method has been developed for the synthesis of tetrahydrobenzo[α] xanthen-11-one using sodium acetate. The reaction was performed via three components: β-naphthol, dimedone with various aromatic aldehydes under solvent-free microwave irradiation and conventional heating condition. We observed an efficient result for microwave synthesis than conventional heating. The synthesized tetrahydrobenzo[α]xanthen-11-one (4a–l) was screened for their antimicrobial activity against two bacteria (Escherichia coli and Bacillus subtilis) and two fungal strains (Aspergillus niger and Saccharomyces cerevisiae). The synthesized products: 9, 10-dihydro-9, 9-dimethyl-12-(4-nitrophenyl)-8H-benzo[a]xanthen-11(12H)-one, 9, 10-dihydro-9, 9-dimethyl-12-(2, 4-dichlorophenyl)-8H-benzo[a]xanthen-11(12H)-one, 9, 10-dihydro-9, 9-dimethyl-12-(6-methyl-4-oxo-4H-chromen-3-yl)-8H-benzo[a]xanthen-11(12H)-one exhibit good antimicrobial activity. The developed protocol is graced with appealing advantages such as high purity, simple operation, excellent yields, inexpensive and easy availability of catalyst.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
