Abstract
SOD2 deficiency promotes aging phenotypes in mouse skin
Highlights
Reactive oxygen species (ROS) are essential for survival and pose serious risks to that survival
Compromised homeostatic pathways lead to elevated ROS levels that may result in the damage of cellular components
SOD2 is a mitochondrial matrix protein that converts the superoxide anion (O2-) to hydrogen peroxide (H2O2), which is in turn, converted to molecular oxygen and water by catalase and peroxiredoxins
Summary
Reactive oxygen species (ROS) are essential for survival and pose serious risks to that survival. Compromised homeostatic pathways lead to elevated ROS levels that may result in the damage of cellular components (i.e., proteins, lipids, DNA). In this Aging paper, the Campisi group showed that normal aged mice exhibit impaired mitochondrial complex II activity and increased frequencies of senescent cells.
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