Abstract
We measured SOD activity, NOx, and free SH level in wobbler mice. Their NOx levels in both brain and spinal cord were significantly higher than those in healthy littermates. In addition, the SOD activity in both brain and spinal cord was lower with a significant difference. Furthermore, it was found that the free SH level in their brain was also lower. These results suggest that free radical might play some role of the motoneuron degeneration in wobbler mice.
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