SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study.

Yuanlin Xie,Taoming Li,Meiling Zuo,Lichen Dong,Syed Sameer Aga,Lingyun Liu,Dabin Kuang,Zhousheng Yang

doi:10.1155/2021/8445461

Abstract

Endothelial inflammation and vascular damage are essential risk factors contributing to hypertension. Suppressor of cytokine signaling 3 (SOCS3) is involved in the regulation of multiple inflammatory pathways. A large number of studies have shown that the anti-inflammatory effect of SOCS3 in hypertension, obesity, and allergic reactions has brought more insights into the inhibition of inflammation. Therefore, we selected a tagSNP of SOCS3 (rs8064821) to investigate whether they are contributing to the risk of hypertension in the Chinese population. In total, 532 patients with hypertension and 569 healthy controls were enrolled for two central of China. SOCS3 rs8064821 C>A polymorphism was genotyped using TaqMan assay. SOCS3 rs8064821 CA genotype was associated with an increased risk of hypertension (OR = 1.821, 95%CI = 1.276-2.600, P = 0.001). Rs8064821 A allele was associated with higher SOCS3 mRNA level in PBMCs from healthy donors. SOCS3 rs8064821 C>A polymorphism may contribute to the risk of hypertension in the Chinese population by regulating the expression of SOCS3.

Highlights

Hypertension is the leading contributing factor to all-cause global mortality Manosroi & Williams [1]
We investigated whether Suppressor of cytokine signaling 3 (SOCS3) gene polymorphism was involved in the risk of hypertension in the Chinese population using individuals from two centers
We observed that the rs8064821 C>A polymorphism affected the expression level of SOCS3 in healthy subjects, with subjects heterozygote for the rs8064821 genotype showing significantly higher mRNA level of SOCS3 than the AA genotype in Peripheral Blood Mononuclear Cells (PBMCs)

Summary

Introduction

Hypertension is the leading contributing factor to all-cause global mortality Manosroi & Williams [1]. Hypertension affects over 1.2 billion individuals worldwide and has become the most critical and expensive public health problem Durham & Palmer [2]; Manosroi & Williams [1]; Rossier, Bochud, & Devuyst [3]; Samson, Ayinapudi, Le Jemtel, & Oparil [4]. It is the main risk factor for stroke (ischemic and hemorrhagic) and coronary artery disease Manosroi & Williams [1]; Rossier et al [3]. Identifying new risk sites for hypertension may help promote early diagnosis and therapeutic intervention of the disease

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Conclusion