Abstract
Aim: Oxidative stress and JAK/STAT pathway are implicated in diabetes micro- and macrovascular complications. SOCS family of endogenous JAK/STAT regulators is an attractive target for therapeutic intervention. Therefore, we investigated the beneficial effect of two different SOCS1-based therapies (adenovirus-mediated gene transfer and kinase-inhibitory region peptidomimetic) to combat oxidative damage in a mouse model of diabetic atherosclerosis and nephropathy.
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