Abstract
BackgroundHuman papillomavirus (HPV) infection plays key role in the development of cervical cancer. The purpose of this study was to investigate socioeconomic and lifestyle factors associated with HPV infection in pregnant women in Beijing, China.MethodsAn age matched case-control study designed with 66 women as the case group (HPV positive) and 132 women as the control group (HPV negative) was carried out in two hospitals in Beijing. Socioeconomic and lifestyle factors were obtained using a standard questionnaire. Cervical cells from study subjects were collected for HPV detection. An unconditional logistic regression model with backward stepwise selection was performed to predict the odds ratio (OR) and 95% confidence interval (CI) for the significant factors associated with HPV infection.ResultsThe analyses of present data show that alcohol consumption during pregnancy was the strongest significant factor (OR = 3.35, 95% CI = 1.40–8.03, p = 0.007) when comparing the case (HPV positive) group with the control (HPV negative) group. There were no statistical differences observed in any of the socioeconomic factors when comparing the case and control groups.ConclusionThe results of this study may help to prevent HPV infection in China by providing evidence to support improving the national policy on alcohol restriction and introducing public health interventions, especially for pregnant women in Beijing.
Highlights
Human papillomavirus (HPV) infection plays key role in the development of cervical cancer
Plain English summary Human papillomavirus (HPV) infection plays a key role in the development of cervical cancer
The prevalence of HPV infection is increasing in China, but the socioeconomic and lifestyle factors associated with HPV infection in pregnant Chinese women have not been systematically analyzed
Summary
Human papillomavirus (HPV) infection plays key role in the development of cervical cancer. The purpose of this study was to investigate socioeconomic and lifestyle factors associated with HPV infection in pregnant women in Beijing, China. Unlike other cancers with broad spectrum etiologies, cervical cancer is primarily caused by sexually transmitted human papillomavirus (HPV) infection [2,3,4,5]. A series of studies have been performed to assess the prevalence of HPV genotypes in several regions in China, such as Yunnan Province [8], Zhejiang Province [9] and Guangdong Province [10], few studies have been reported in Beijing, the capital city in China. Other risk factors are still controversial including tobacco smoke [15], alcohol consumption, and socioeconomic factors such as education, occupation, and household income [16]
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