Abstract
In developing countries, acquired bacterial resistance to antimicrobial agents is common in isolates from healthy persons and from persons with community-acquired infections. Complex socioeconomic and behavioral factors associated with antibiotic resistance, particularly regarding diarrheal and respiratory pathogens, in developing tropical countries, include misuse of antibiotics by health professionals, unskilled practitioners, and laypersons; poor drug quality; unhygienic conditions accounting for spread of resistant bacteria; and inadequate surveillance.
Highlights
In developing countries, acquired bacterial resistance to antimicrobial agents is common in isolates from healthy persons and from persons with community-acquired infections
Acquired bacterial resistance is common in isolates from healthy persons and from patients with community-acquired infections in developing countries, where the need for antibiotics is driven by the high incidence of infectious disease [1]
Antibiotic use provides selective pressure favoring resistant bacterial strains; inappropriate use increases the risk for selection and dissemination of antibiotic-resistant bacteria, which are placed at a competitive advantage
Summary
In developing countries, acquired bacterial resistance to antimicrobial agents is common in isolates from healthy persons and from persons with community-acquired infections. Acquired bacterial resistance is common in isolates from healthy persons and from patients with community-acquired infections in developing countries, where the need for antibiotics is driven by the high incidence of infectious disease [1]. One would expect that drugs more commonly affected by bacterial resistance in developing countries are generally inexpensive and popular broad-spectrum agents [2,3,4,5,13]. Antibiotic use in clinical practice alone cannot explain the high frequency of resistant organisms in developing countries [14,15].
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