Socio Clinical Profile of MDR TB Cases: A Study at DR –TB Center, SCB Medical College & Hospital

Abstract

Introduction India accounts for about one-fourth of the global burden of MDR-TB. This study aims to evaluate clinical profile and factors associated with tuberculosis drug resistance among patients from eastern India. Method All the MDR-TB cases registered under RNTCP PMDT services were included in the study between 1st April-2013 to 31st March 2014. This observational study was carried out by the Department of Pulmonary Medicine, SCB Medical College, Cuttack. Result Between April 2013 and March 2014, the IRL ATDC Center collected a total of 2205 sputum samples. Out of 2205, 245 (11%) had both INH and Rifampicin, 68 (3%), INH resistance, 359 (16.3%), and 51 (2.3%) had sputum contaminated with report awaiting. Mean age MDR TB was 35.6 (Standard deviation 13.769). The study shows 14.3% of the TB patients were illiterate. Out of 126 cases of MDR-TB presented with 140 co- morbidities at DR-TB Center. Discussion High rate of drug resistance pattern was found among the new sputum smear positive pulmonary tuberculosis patients and also high MDR tuberculosis. Risk factors such as age, sex, smoking, and alcoholism were independently associated with pulmonary MDR-TB. Our study concluded that young age, male sex, smear positivity, treatment failure, and the combination of smoking and alcoholism were identified as risk factors for Tuberculosis mortality.