Abstract
Decreased health-related quality of life (HRQoL) is well known for the previous ICU population after critical care, and many factors are of importance for this outcome. We have in a recent study shown that pre-existing disease is most important. This finding was made when comparing a control population adjusting for co-morbidities and approximately 50% of the decrease in HRQoL was attributed to co-morbidities. Therefore, there must be other factors that contribute to the HRQoL decrease. In HRQoL research it has been shown that social support also is important for the HRQoL experience. In the southeast of Sweden, two neighbouring large cities are known to have different social support patterns depending on their differences in social structure. We hypothesized that the social support is different between the patients coming from city A's ICU compared with city B. The aim of this study was to examine to what extent social support affected HRQoL outcome in the follow-up of these patients in general and to what extent it differed between the patients of ICUs of the different cities.
Highlights
We previously showed that erythropoietin (EPO) attenuates the morphological signs of spinal cord ischemia/reperfusion (I/R) injury in swine [1] without, improving neurological function
The clinical use of EPO has been cautioned most recently due to serious safety concerns arising from an increased mortality in acute stroke patients treated with EPO and simultaneously receiving systemic thrombolysis [2]
Sodium 4-phenylbutyrate (PBA) has been reported to act as a chemical chaperone inhibiting Unfolded protein response (UPR)-mediated apoptosis triggered by ischemia in various organs other than the heart
Summary
We previously showed that erythropoietin (EPO) attenuates the morphological signs of spinal cord ischemia/reperfusion (I/R) injury in swine [1] without, improving neurological function. Methods We studied 90 patients affected by severe sepsis or septic shock previously enrolled in a prospective trial regarding the impact of glycemic control on inflammation and coagulation. In a retrospective analysis of the data from the SBITS-trial [1] we investigated whether the initial level of serum IgG on admission to the hospital in patients with sepsis and septic shock (before the first administration of the first dose of intravenous immunoglobulins) could be seen as a prognostic parameter for the primary outcome, lethality on day 28, or the secondary endpoints, lethality on day 7 or on the ICU. The aim of this analysis was to assess the impact of real-time continuous glucose monitoring (CGM) on glucose variability in critically ill patients receiving intensive insulin therapy (IIT) Methods This is the post hoc analysis of a prospective, randomized, controlled trial [2]. Respecting anonymity we have statistically evaluated 103 replies (response rate was 13.8%) and compared with data from other European countries
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