Abstract
Rearing environment plays a vital role in maintaining physical and mental health of both animals and humans. Plenty of studies have proved that physical environment enrichment in adolescence has protective effects on emotion, social behavior, learning and memory deficits. However, the following effects of social environment enrichment in adolescence remain largely elusive. Using the paradigm of companion rotation (CR), the present study found that social environment enrichment reduced anxiety-like behaviors of early adult male C57BL/6J mice. CR group also showed significantly higher expression of tyrosine hydroxylase in the ventral tegmental area and dopamine 1 receptor mRNA in the nucleus accumbens shell than control group. Taken together, these findings demonstrate that CR from adolescence to early adulthood can suppress the level of anxiety and upregulate dopaminergic neuron activity in early adult male C57BL/6J mice.
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