Abstract
The effect of complete social deprivation in early postnatal ontogenesis on adult behavior in Wag/Rij rats with a genetic predisposition to the development of absence epilepsy was studied. From the 2nd to the 8th day of life, a 3-hour daily isolation of the pups from the mother and siblings was performed, the control animals were handled. In adulthood, offspring behavior was tested in an elevated plus-maze, an open field, and for an ability to learn the conditioned reflex of active avoidance. In isolated earlier rats, an increase in emotional reactivity, exploratory behavior in a potentially dangerous space, the speed of learning a conditioned reflex with negative painful reinforcement, and a disturbance of the formation of a defensive reaction were revealed. It is assumed that high emotional reactivity creates the prerequisites for the development of absence epilepsy.
Highlights
An important factor in early ontogenesis, which affects the morphological and functional development and manifestation of adaptive behavior in adulthood, is species-specific information
The effect of complete social deprivation in early postnatal ontogenesis on adult behavior in Wag/Rij rats with a genetic predisposition to the development of absence epilepsy was studied
The effect of isolation on behavior in an elevated plus-maze Isolation in early ontogenesis influenced on the behavior of rats in an elevated plus-maze
Summary
An important factor in early ontogenesis, which affects the morphological and functional development and manifestation of adaptive behavior in adulthood, is species-specific information. The deprivation of sensory input in the first 3 weeks of life due to clipping of vibrissae causes a change in the formation of early behavioral reactions [1], and vibrissectomy from the 9th to the 20th day of postnatal ontogenesis determines a more stereotyped behavior of adult animals in the new environment [2].
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