Social Communication and Theory of Mind in Boys with Autism and Fragile X Syndrome

Molly Losh,John Sideris,Jessica Klusek,Gary E Martin,Abigail L Hogan-Brown

doi:10.3389/fpsyg.2012.00266

Molly Losh, John Sideris + Show 3 more

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https://doi.org/10.3389/fpsyg.2012.00266

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Abstract

Impairments in the social use of language, or pragmatics, constitute a core characteristic of autism. Problems with pragmatic language have also been documented in fragile X syndrome (FXS), a monogenic condition that is the most common known genetic cause of autism. Evidence suggests that social cognitive ability, or theory of mind, may also be impaired in both conditions, and in autism, may importantly relate to pragmatic language ability. Given the substantial overlap observed in autism and FXS, this study aimed to better define those social-communicative phenotypes that overlap in these two conditions by comparing pragmatic language ability and theory of mind in children with idiopathic autism and children with FXS, with and without autism, as well as children with Down syndrome and typically developing controls. We further examined correlations between these cognitive-behavioral phenotypes and molecular genetic variation related to the Fragile X Mental Retardation-1 gene (FMR1) in the FXS group. Results indicated that children with idiopathic autism and those with FXS and autism performed comparably on direct-assessment measures of pragmatic language and theory of mind, whereas those with FXS only did not differ from controls. Theory of mind was related to pragmatic language ability in all groups. Pragmatic language and theory of mind also correlated with genetic variation at the FMR1 locus (Cytosine-Guanine-Guanine repeats and percent methylation). These results point toward substantial overlap in the social and language phenotypes in autism and FXS and suggest a molecular genetic basis to these phenotypic profiles.

Highlights

TO fragile X syndrome (FXS) AND ITS OVERLAP WITH AUTISM Fragile X syndrome is the most frequent known hereditary cause of intellectual disability (ID) (Dykens et al, 2000; Hagerman and Hagerman, 2002), with the full mutation estimated to occur in approximately 1 in 2,500 to 1 in 5,000 individuals (Hagerman, 2008; Coffee et al, 2009; FernandezCarvajal et al, 2009)
Whether impairments in pragmatic language and theory of mind may be related in both populations is not known. This study addressed these questions by comparing pragmatic language ability and theory of mind in children with idiopathic autism, children with FXS with and without autism, children with Down syndrome (DS), and typically developing (TD) children
By comparing the pragmatic language abilities of children with idiopathic autism or FXS, with children with DS and TD children, this study aimed to determine the extent to which pragmatic language impairment may overlap in autism and FXS, and may potentially be tied to underlying molecular genetic variation related to Fragile X Mental Retardation-1 gene (FMR1), the gene that causes FXS

Summary

Introduction

TO FXS AND ITS OVERLAP WITH AUTISM Fragile X syndrome is the most frequent known hereditary cause of ID (Dykens et al, 2000; Hagerman and Hagerman, 2002), with the full mutation estimated to occur in approximately 1 in 2,500 to 1 in 5,000 individuals (Hagerman, 2008; Coffee et al, 2009; FernandezCarvajal et al, 2009). FMRP is thought to be critical for typical brain development (Devys et al, 1993; Jin and Warren, 2003), and its deficiency in FXS is believed to underlie the physical and cognitive-behavioral characteristics of the syndrome. Autistic characteristics observed in individuals with FXS include stereotypic and repetitive behaviors, poor eye contact, and social avoidance (Reiss and Freund, 1992; Hagerman and Hagerman, 2002). Approximately 2–6% of individuals with autism test positive for the fragile X mutation (Hagerman, 2006)

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