SO03 CRITICAL ANALYSIS OF TREATMENT FAILURE FOLLOWING COMPLETE CYTOREDUCTIVE SURGERY AND PERIOPERATIVE INTRAPERITONEAL CHEMOTHERAPY FOR PERITONEAL DISSEMINATION FROM APPENDICEAL MUCINOUS NEOPLASMS

Abstract

Purpose The objective of this data analysis was to study treatment failure after complete cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) for peritoneal dissemination from appendiceal mucinous neoplasms.Methodology Prior to June 2006, 402 patients with peritoneal dissemination from appendiceal mucinous neoplasms underwent complete cytoreduction and PIC at the Washington Cancer Institute. Patient characteristics, pathologic features and treatment‐related data were obtained from a prospective database. Survival analyses were performed using Kaplan‐Meier method and Cox Regression model.Results After a median follow‐up of 66 months, the 5‐ and 10‐year overall survival rates for the entire 402 patients were 90% and 85%, respectively. The 5‐ and 10‐year progression‐free survival rates were 70% and 67%, respectively. Disease progression was the only independent risk factor for a reduced overall survival. One hundred and eleven patients (28%) developed progressive disease. Of these, 98 patients underwent second‐time and 26 patients third‐time CRS and PIC. Complete cytoreduction after repeat surgery was the only independent prognostic factor for an improved survival. The most common sites of treatment failure were on the small bowel and in the pelvis.Conclusions The present study reported the patterns of treatment failure after complete cytoreduction and demonstrated that a disease‐free state is important for long‐term survival in peritoneal dissemination from appendiceal mucinous neoplasms. Repeat complete cytoreduction should be pursued when possible and is associated with an improved overall survival in patients with recurrent disease.