Abstract
Wnt signaling is essential for a vast array of developmental and physiological processes, including cardiogenesis and disease states like cancer and bone disease. During Wnt/β-catenin signaling, trafficking mechanisms play essential roles in receptor localization at the plasma membrane and in intracellular endosomal compartments, before, during and after activation. Although endocytosis (clathrin-dependent and -independent) and localization of LRP6-GSK3 signalosomes to multivesicular bodies are required for proper signaling transduction, the mechanisms that regulate the sorting of receptors and co-receptors towards specific endosomal compartments are largely unknown.
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