Abstract
This study describes the synthesis, characterization and antimicrobial activity evaluation of 2-(1-{3-[(7-chloroquinolin-4-yl)amino]phenyl}ethylidene)hydrazinecarboxamide (5), which was designed and synthesized applying a molecular hybridization strategy, considering two pharmacophoric portions: 7-chloro-4-aminoquinoline and semicarbazone; both fractions have been related to antimicrobial activity exhibited by a series of derivatives synthesized. Compound 5 was characterized using 1H NMR, 13C NMR and Electrospray Ionization Mass Spectrometry (ESI-MS) studies. Biological evaluation showed that compound 5 exhibited antimicrobial activity against bacteria Gram (-) Pseudomona aeruginosa, comparable with the activities corresponding to Amikacin, Ampicillin/Sulbactam and Ofloxacin.
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