Abstract
BackgroundThe aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of late toxicity studying our group of patients who underwent a Single Shot 3D-CRT PBI (SSPBI) after BCS (breast conserving surgery).MethodsA total of 57 breast cancer patients who underwent SSPBI were genotyped for SNPs (single nucleotide polymorphisms) in XRCC1, XRCC3, GST and RAD51 by Pyrosequencing technology. Univariate analysis (ORs and 95% CI) was performed to correlate SNPs with the risk of developing ≥ G2 fibrosis or fat necrosis.ResultsA higher significant risk of developing ≥ G2 fibrosis or fat necrosis in patients with: polymorphic variant GSTP1 (Ile105Val) (OR = 2.9; 95%CI, 0.88-10.14, p = 0.047).ConclusionsThe presence of some SNPs involved in DNA repair or response to oxidative stress seem to be able to predict late toxicity.Trial RegistrationClinicalTrials.gov: NCT01316328
Highlights
The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities
To these study purposes, i.e. determining polymorphisms predicting late toxicity, we recruited 57 patients treated with Single Shot 3D-CRT Partial Breast Irradiation (PBI) (SSPBI) from March 2006 to January 2008
The single dose is expected to be more difficult to be repaired, enhancing the scenarios in which the mechanism of protect against reactive oxygen species (ROS) damage or DNA repair fails. It is for this reason, we focused our attention on SNPs evaluation that may help design a clinical approach and explain basic phenomena such as subcutaneous fibrosis or fat necrosis
Summary
The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of late toxicity studying our group of patients who underwent a Single Shot 3D-CRT PBI (SSPBI) after BCS (breast conserving surgery). Conservative surgery followed by adjuvant radiotherapy (RT) to whole breast has become widely accepted as a standard of care for women with early breast cancer. Irradiation (APBI), where only the Index Area is irradiated in 1-10 fractions at high dose/fraction, has been promoted in phase I-III trials designed to test feasibility and equivalence with standard Whole Breast Irradiation (WBI) in properly selected low risk early breast cancer patients after BCS [5]. The possibility to predict patient outcome based on marker genes correlated with radio-induced toxicity was investigated
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