Abstract
A sensor has been developed for detecting 1-nonanal gas present in the breath of lung cancer patients by combining SnO2 nanosheets with SnO2 nanoparticles and noble metal catalysts. A significant change in the electrical resistance of this sensor was observed with increasing 1-nonanal gas concentration; the resistance decreased by a factor of 1.12 within the range of 1 to 10 ppm at 300 °C. The recovery of the sensor’s resistance after detecting 1-nonanal gas concentrations of 0.055, 0.18, 1, and 9.5 ppm was determined to be 86.1, 84.2, 80.4 and 69.2%, respectively. This high sensitivity is attributed to the accelerated oxidation of 1-nonanal molecules caused by the (101) crystal faces of the SnO2 nanosheets and should provide a simple and effective approach to the early detection of lung cancer.
Highlights
A sensor has been developed for detecting 1-nonanal gas present in the breath of lung cancer patients by combining SnO2 nanosheets with SnO2 nanoparticles and noble metal catalysts
The authors of this paper have recently reported a 1-nonanal gas sensor based on SnO214, in which concentration is determined from the change in the resistance of the sensor that is caused by 1-nonanal oxidizing to CO2 and H2O in the presence of a noble metal catalyst, thereby reducing the SnO2
The bare SnO2 particulate film was found through field emission scanning electron microscopy (FE-SEM) analysis to have a porous surface structure (Fig. 1C,a1,a2), but showed little change after immersion for 20 min due to the small size of the SnO2 nanosheets (Fig. 1C,b1,b2)
Summary
A sensor has been developed for detecting 1-nonanal gas present in the breath of lung cancer patients by combining SnO2 nanosheets with SnO2 nanoparticles and noble metal catalysts. It is known that the breath of lung cancer patients contains traces of 1-nonanal gas[5], which as a by-product of the destruction of cell membranes, increases in concentration in relation to the damage caused by smoking[6] This raises the possibility of creating 1-nonanal gas sensors for on-site monitoring in households for early detection, the difficulty of oxidizing a large molecule such as 1-nonanal creates a significant hurdle to the development of highly sensitive detector materials. A limited change in resistance has so far been achieved, greater optimisation of the structure should greatly increase the sensitivity of this detector material To this end, an improved SnO2 nanosheet detector for the detection of lung cancer[16] has been developed that combines SnO2 nanosheets with SnO2 nanoparticles and noble metal catalysts, the sensing properties of which are discussed
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