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Abstract
Respiratory effects of single positive and negative pressure pulses (PPP, NPP) applied to the functionally isolated upper airways (UA) were studied in 11 anaesthetized cats breathing spontaneously through a tracheal tube. The UA pressure and the changes of trachela airflow were recorded and the blood pressure and electrocardiogram were occasionally monitored. Sniff-like NPP of 20 to 110 cm H 2O or −14 to −140 cm H 2O. The responses to NPP but also to PPP characterized by high peak inspiratory flow, mean inspiratory flow and tidal volume ( PIF = 312.5 ± 64.3 and 231.1 ± 21.7 ml·sec −1; V ti = 178.3 ± 46-7 and 110.1 ± 14.4 ml·sec −1; V t = 40.9 ± 8/3 and 22.5 ± 1.7 ml ) resembled closely the aspiration reflex elicited by mechanical stimulation of the pharyngeal wall. Occasionally, sneezing, minor modifications of breathing pattern and solitary forced inspirations could be induced by lower pressures. The results indicate that the sudden pressure stimulation of the UA evokes vigorous respiratory resposnes including the aspiration reflex. These reflexes and their alterations may contribute to development or release of both UA obstruction and opnoea, at least in cats.
Published Version
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