SNHG10 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Prostate Cancer.

Qiang Chen,Siyuan Wang,Wenjie Xie,Zhilong Li,Shengqiang Fu,Ming Ma,Yutang Liu,Ting Sun,Xiaorong Yang,Zhicheng Zhang,Binbin Gong

doi:10.3389/fcell.2021.731042

Abstract

SNHG10 is a long non-coding RNA (lncRNA) found to be overexpressed in multiple human cancers including prostate cancer (PC). However, the underlying mechanisms of SNHG10 driving the progression of PC remains unclear. In this study, we investigated the role of SNHG10 in PC and found that SNHG10 expression was significantly increased in datasets extracted from The Cancer Genome Atlas. Increased expression of SNHG10 was related to advanced clinical parameters. Receiver operating curve analysis revealed the significant diagnostic ability of SNHG10 (AUC = 0.805). In addition, immune infiltration analysis, and GSEA showed that SNHG10 expression was correlated with oxidative phosphorylation and immune infiltrated cells. Finally, we determined that SNHG10 regulated cell proliferation, migration, and invasion of PC in vitro. In conclusion, our data demonstrated that SNHG10 was correlated with progression and immune infiltration, and could serve as a prognostic biomarker for PC.

Highlights

Prostate cancer (PC) is the most frequently diagnosed malignancy among men worldwide accounting for approximately 21% of new cancer cases in 2020 (Siegel et al, 2020)
We compared the expression of Small nucleolar RNA host gene 10 (SNHG10) between normal and prostate cancer in GSE70770, and found that SNHG10 was overexpressed in cancer tissues (P < 0.001) (Figure 2C)
Kaplan-Meier survival analysis was used to investigate the relationship of SNHG10 expression and overall survival (OS) or progressionfree survival (PFS) in the prostate cancer (PC) patients of The Cancer Genome Atlas (TCGA) data

Summary

Introduction

Prostate cancer (PC) is the most frequently diagnosed malignancy among men worldwide accounting for approximately 21% of new cancer cases in 2020 (Siegel et al, 2020). Recent studies have indicated that lncRNAs might play a crucial role in the progression of different cancers (De Troyer et al, 2020; Luo et al, 2020; Statello et al, 2021). LncRNA PVT1 plays a pivotal role in PC progression by inhibiting KIF23 expression via enriched miR-15a-5p levels (Wu et al, 2020). Small nucleolar RNA host gene 10 (SNHG10) has been reported to be a cancer-promoting gene in various human cancers. SNHG10 has been identified as having a tumor facilitator role in hepatocellular carcinoma and gastric carcinoma (Lan et al, 2019; Zhang et al, 2020). SNHG10 Promotes Prostate Cancer Progression the clinical value of SNHG10 in PC has not been explored. This study aimed to investigate the role of SNHG10 in the progression of PC

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