Abstract
Malignant rhabdoid tumors (MRTs), a pediatric cancer that frequently arises in the kidney, lack SNF5, a subunit of the SWI/SNF chromatin-remodeling complex. Recent studies have also shown that BAF180/PBRM1, another SWI/SNF subunit, was mutated in adult renal carcinoma. So now BAF180 is recognized as tumor suppressor gene. Intriguingly, both SNF5 and BAF180 regulate the cell cycle through control of expression of p21. Therefore, we hypothesized that SNF5 loss may affect BAF180 function(s) during MRT development.
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