Abstract
Approximately 40 % of newly discovered chemical entities have low solubility and possess low bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) have recently become very popular because of their remarkable ability to deliver drugs with poor absorption using lipids as carriers. Self-emulsifying drug delivery (SEDDS) systems are one type of LBDDS employed for the incorporation of hydrophobic drugs. SEDDS are classified into self-micro emulsifying drug delivery systems (SMEDDS) and self-nano emulsifying drug delivery systems (SNEDDS) based on the droplet size of the dispersed phase. The present review focus on the mechanism of drug absorption from lipid-based nanocarriers systems, in vitro assessment of self-emulsification, insights of SNEDDS, factors affecting the formulation of SNEDDS, and its applications.
Highlights
More than 40% of NCEs are practically insoluble in water. Many of these promising active compounds are not considered in clinical-stage development [6]
The present review focuses on the mechanism of drug absorption from lipid-based nanocarriers systems, in vitro assessment of self-emulsification, an overview of self-nano emulsifying drug delivery systems (SNEDDS), factors affecting the formulation of SNEDDS, formulation insights, and its biopharmaceutical applications
Construction of pseudo ternary phase diagram is a critical step for developing self-micro emulsifying drug delivery systems (SMEDDS)/SNEDDS
Summary
The oral route is commonly used for drug delivery because of its safety [1], comfort [2], minimum effort [3], and greater patient compliance [4]. Construction of pseudo ternary phase diagram is a critical step for developing SMEDDS/SNEDDS lipid-based formulation [16], which self-disperses as thermodynamically stable nano-drug carrier in GI lumen. It will provide information on phase behavior between different formulation components. The formulation of SNEDDS pseudo-ternary phase diagrams plays a major role in selecting optimal oil concentrations, surfactant/cosurfactants, co-solvents needed to solubilize and stabilize the SNEDDS [28]. These systems are prepared on a simple vortex mixer. Table 6: shows some of the examples of SSNEDDS by using three methods
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