Abstract
Abstract Sneddon syndrome (SS) is a rare disorder that has a variety of pathologic associations, often described as the first cutaneous manifestation of antiphospholipid syndrome. Sneddon syndrome is characterized by livedo racemosa (LR), cerebrovascular symptoms, and microangiopathic disease in the deep vessels on skin biopsy. We discuss a case of a 55-year-old woman with a complex history of arterio-occlusive disease who presented with a violaceous and painful rash on her thigh. Skin biopsy showed thrombotic vasculopathy. Her clinical and cutaneous manifestations led to the question and the diagnosis of SS. Our case is one of the few cases of SS where LR occurred long after cerebrovascular disease. We discuss the range of skin biopsy findings of LR and approach to SS from a dermatopathologic perspective.
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