Abstract
Metronidazole-induced central vestibular syndrome (CVS) is uncommon in horses. A case of CVS following treatment with metronidazole at therapeutic doses is reported. An adult male mixed breed horse was submitted to antimicrobial therapy with metronidazole (15 mg.kg-1 IV), penicillin-streptomycin (22.000UI.kg-1 IM) and gentamicin (6.6 mg.kg-1 IV) following small intestinal resection. Clinical signs consistent with CVS (ataxia, horizontal gaze nystagmus, strabismus and head tilt) developed on the 12th post-operative day. Metronidazole administration was immediately discontinued. Initial disease progression followed by progressive improvement of clinical signs from day 10 after recognition of CVS manifestations was observed. Metronidazole-induced CVS diagnosis was based on typical CVS manifestations, medical history and remission of clinical signs following discontinuation of treatment.
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