Abstract
The carriers of a rearrangement involving with chromosome 21 have a potential risk of genetically unbalanced conceptions, which may result in liveborn children with Down syndrome. Reproductive risks for couples carriers of a balanced Robertsonian translocation depends on the rearranged chromosomes and the sex of the carrier. This article aims to analyze the segregation and reproductive trend of a rare 15/21 translocation in five generations of a family. It was considered the current advances in reproductive technology as a possibility to prevent fetal aneuploidia. Given the genetic risk, the preimplantation diagnosis appears also as an alternative to avoid the option of an unwanted later abortion and to obtain a healthy progeny.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
