Abstract
Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl<sub>2</sub>·2H<sub>2</sub>O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl<sub>2</sub>·2H<sub>2</sub>O permits versatility in the solvent-free reaction of α-hydroxy ketones with ammonium acetate to give the corresponding substituted pyrazines in good to excellent yields.
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