Abstract
Productive elongation Modes of P-TEFb Recruitment: TFs (e.g., MYC, NF-κB) Mediator (Med26 subunit or Cdk8 module) Acetylated histones and Brd4 Other elongation factors as part of the superelongation complex CRE DNA-binding transcription factors (TFs) associate with cis-regulatory elements (CRE) to promote assembly of the PIC. TFs can stimulate PIC formation directly through interactions with the Mediator complex and help recruit the general transcription factors (GTFs). TFs also recruit coactivators that can remove nucleosomes from the promoter or modify histone proteins, for example by acetylation (Ac) or methylation (Me).
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