Abstract
The essential role of DNA methylation in X chromosome inactivation and imprinting is widely recognized, but we know little about tissue-specific DNA methylation or DNA methylation changes in regulatory regions. Several international epigenome projects, including the Human Epigenome Project, plan to generate detailed maps of DNA methy-lation in normal cells and cells that are altered during disease pathogenesis. The SnapShot shows a summary of our current knowledge of the DNA methylation patterns in normal human cells and in human cells in different disease states. In normal cells, DNA methylation is restricted to a few tissue-specific genes (white arrow heads) and imprinted genes (gray arrow heads) and throughout the inactive X (X
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