Abstract
Ras is a monomeric membrane-associated GTP-binding protein that regulates cell proliferation and survival in response to extracellular stimuli, such as activation of epi-dermal growth factor receptor (EGFR) or T cell receptor (TCR). Originally identified as an oncogene in murine sarcoma viruses, activating mutations in Ras have been found in about 30% of human tumors. Dysregulation of the Ras signaling pathway plays a key role in the progression of cancer. When bound to GTP, Ras is active and stimulates several downstream targets by direct interactions. Ras has intrinsic GTPase activity, which can be activated by GTPase-activating proteins (GAPs) such as the
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