Abstract
1 TM domain; C-term in IMS and N-term in the matrix. IBM & CJ; self-oligomerizes, binds MICOS/MINOS/MitOS components and Sam50, Tob38, Ugo1, Fzo1.Yeast are viable but exhibit altered mtDNA inheritance and decreased respiratory growth. Mammals and worms exhibit increased ROS production and apoptosis.Loss of CJ, altered cristae structure, accumulation of cristae stacks and cristae rims. Higher membrane potential.Mos1 (Mcs10, Mio10, YC1057C-A)
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