Abstract
We present a snapshot hyperspectral retinal camera with the Image Mapping Spectrometer (IMS) for eye imaging applications. The resulting system is capable of simultaneously acquiring 48 spectral channel images in the range 470 nm–650 nm with frame rate at 5.2 fps. The spatial sampling of each measured spectral scene is 350 × 350 pixels. The advantages of this snapshot device are elimination of the eye motion artifacts and pixel misregistration problems in traditional scanning-based hyperspectral retinal cameras, and real-time imaging of oxygen saturation dynamics with sub-second temporal resolution. The spectral imaging performance is demonstrated in a human retinal imaging experiment in vivo. The absorption spectral signatures of oxy-hemoglobin and macular pigments were successfully acquired by using this device.
Highlights
Hyperspectral retinal imaging is a novel technique for non-invasive ocular diagnosis [1,2]
Since no scanning is employed, this hyperspectral retinal camera does not suffer motion artifacts or pixel misregistration problems which are inevitable in scanning-based hyperspectral retinal cameras
The acquisition of multichannel retinal images and the recovery of the spectral signatures of oxy-hemoglobin, macular pigment and optic disc drusen demonstrated the capability of this device in eye imaging applications
Summary
Hyperspectral retinal imaging is a novel technique for non-invasive ocular diagnosis [1,2]. Incorporation of scanning-based hyperspectral imagers in retinal imaging causes severe motion artifacts and pixel misregistration problems because the human eye is constantly moving. To overcome this limitation, recently a snapshot hyperspectral retinal camera which utilizes a computed tomographic imaging spectrometer (CTIS) has been developed for fundus imaging [8]. The IMS is a parallel acquisition hyperspectral imager that can capture hyperspectral datacubes without scanning It allows full light throughput across the whole spectral collection range due to its snapshot operating format. The previously unknown spectral reflectance of an optic disc druse was measured
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