Abstract
Healing is a complex process with many interfering factors. The objective of this work was to evaluate regeneration strength of non-pregnant adult dog uterus when snake venom derived fibrin adhesive is used to reinforce hysterorrhaphy. Maximum limit and rigidity were analyzed. Twenty uterine horns from 10 dogs were hysterotomized and distributed into 2 equal groups. Hysterorrhaphy was performed using the Shimieden-Cushing double layer suture. In one group, animals received snake venom derived fibrin adhesive as reinforcement. Although neither variable was significantly different, our results showed higher rigidity values in the adhesive group. This can be attributed to the adhesive’s effect on organ elasticity or to more granulation tissue formed in the uterine scar.
Highlights
The reliable way to determine the mechanical properties of biological materials is by standard mechanical tests, which provide comparable and reproducible results [24]
The more mechanical characteristics grouped in traction tests of a specific biological material, the more conclusive the test, as it is believed to be closer to real functional conditions [16]
In this work we studied the maximum limit and rigidity of mechanical traction in dog uterus hysterorrhaphy with and without snake venom derived fibrin adhesive used as a reinforcing agent
Summary
The reliable way to determine the mechanical properties of biological materials is by standard mechanical tests, which provide comparable and reproducible results [24]. Material is submitted to two opposing forces, applied at different points and in opposite directions causing longitudinal stretching and transverse reduction. This provides a curve (load x deformation), which for small forces, is a straight line (elastic phase), corresponding to deformation proportional to force, followed by a curve (plastic phase), in which there is no proportionality between deformation and force [3]. The more mechanical characteristics grouped in traction tests of a specific biological material, the more conclusive the test, as it is believed to be closer to real functional conditions [16] This way, several conditions have been tested in different tissues such as muscle, ligaments, tendons, etc. In this work we studied the maximum limit and rigidity of mechanical traction in dog uterus hysterorrhaphy with and without snake venom derived fibrin adhesive used as a reinforcing agent
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