SMR/Theta Neurofeedback Training Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment: A Pilot Study.

Ya-Huei Wu,Hermine Lenoir,Anne-Sophie Rigaud,Eric Azabou,Sylvain Chevallier,Fabienne Marlats,Leila Djabelkhir-Jemmi,Guillaume Bao,Marouane Boubaya

doi:10.3389/fnagi.2020.00147

Abstract

Background: Neurofeedback (NF) training, as a method of self-regulation of brain activity, may be beneficial in elderly patients with mild cognitive impairment (MCI). In this pilot study, we investigated whether a sensorimotor (SMR)/theta NF training could improve cognitive performance and brain electrical activity in elderly patients with MCI.Methods: Twenty elderly patients with MCI were assigned to 20 consecutive sessions of sensorimotor (SMR)/theta NF training, during 10 weeks, on a basis of two sessions each week. Neuropsychological assessments and questionnaires, as well as electroencephalogram (EEG), were performed and compared between baseline (T0), after the last NF training session at 10 weeks (T1), and 1-month follow-up (T2).Results: Repeated measures ANOVA revealed that from baseline to post-intervention, participants showed significant improvement in the Montreal cognitive assessment (MoCa, F = 4.78; p = 0.012), the delayed recall of the Rey auditory verbal learning test (RAVLT, F = 3.675; p = 0.032), the Forward digit span (F = 13.82; p < 0.0001), the Anxiety Goldberg Scale (F = 4.54; p = 0.015), the Wechsler Adult Intelligence Score–Fourth Edition (WAIS-IV; F = 24.75; p < 0.0001), and the Mac Nair score (F = 4.47; p = 0.016). EEG theta power (F = 4.44; p = 0.016) and alpha power (F = 3.84; p = 0.027) during eyes-closed resting-state significantly increased after the NF training and showed sustained improvement at a 1-month follow-up.Conclusion: Our results suggest that NF training could be effective to reduce cognitive deficits in elderly patients with MCI and improve their EEG activity. If these findings are confirmed by randomized controlled studies with larger samples of patients, NF could be seen as a useful non-invasive, non-pharmacological tool for preventing further decline, rehabilitation of cognitive function in the elderly.Clinical Trial Registration: This pilot study was a preliminary step before the trial registered in www.ClinicalTrials.gov, under the number of NCT03526692.

Highlights

Mild cognitive impairment (MCI) is defined as a symptomatic phase between normal cognitive functioning and mild dementia characterized by cognitive changes with preserved social and occupational functioning (Albert et al, 2011)
Several well-conducted studies have shown the effectiveness of NF in cognitive functions (Arns et al, 2014; Gevensleben et al, 2014) in the field of attention-deficit/hyperactivity disorder (ADHD; Micoulaud-Franchi et al, 2015) epilepsy (Egner and Sterman, 2006), autism (Coben et al, 2010), depression (Micoulaud-Franchi et al, 2015), and anxiety (Hammond, 2005)
We investigate the effects of a SMR/theta NF training protocol on cognitive performances, psycho-affective scores and EEG activities in elderly patients with MCI

Summary

Introduction

Mild cognitive impairment (MCI) is defined as a symptomatic phase between normal cognitive functioning and mild dementia characterized by cognitive changes with preserved social and occupational functioning (Albert et al, 2011). Several well-conducted studies have shown the effectiveness of NF in cognitive functions (Arns et al, 2014; Gevensleben et al, 2014) in the field of attention-deficit/hyperactivity disorder (ADHD; Micoulaud-Franchi et al, 2015) epilepsy (Egner and Sterman, 2006), autism (Coben et al, 2010), depression (Micoulaud-Franchi et al, 2015), and anxiety (Hammond, 2005) This last decade, knowledge regarding principles and technical aspects to achieve the efficient use of EEG NF improved a lot (Marzbani et al, 2016; Arns et al, 2017; Enriquez-Geppert et al, 2017). We investigate the effects of a SMR/theta NF training protocol on cognitive performances, psycho-affective scores and EEG activities in elderly patients with MCI. The goal of this pilot study was beyond understanding the physiological mechanisms of the effects of the NF technique. We investigated whether a sensorimotor (SMR)/theta NF training could improve cognitive performance and brain electrical activity in elderly patients with MCI

Methods

Results

Discussion

Conclusion