Abstract
Coronavirus Diarrhea is a common symptom in patients with coronavirus disease 2019 (COVID-19). Zang et al. used organoid cultures of cells from the epithelial lining of human small and large intestine as an in vitro model system with which to study viral entry and replication in enterocytes. Mature enterocytes expressing the viral receptor were susceptible to productive infection, which was also stimulated by the expression of a protease involved in viral entry. A subset of patients with COVID-19 shed high amounts of viral RNA in feces, but experiments with simulated human colonic fluid suggested that any shed virus would be rapidly inactivated during transit through the colon. Sci. Immunol. 5 , eabc3582 (2020).
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