Smoothed nonparametric estimation for current status competing risks data

Abstract

We study the nonparametric estimation of the cumulative incidence function and the cause-specific hazard function for current status data with competing risks via kernel smoothing. A smoothed naive nonparametric maximum likelihood estimator and a smoothed full nonparametric maximum likelihood estimator are shown to have pointwise asymptotic normality and faster convergence rates than the corresponding unsmoothed nonparametric likelihood estimators. Using the smoothed estimators and the plug-in principle, we can estimate the cause-specific hazard function, which has not been studied previously. We also propose semi-smoothed estimators of the cause-specific hazard as an alternative to the smoothed estimator and demonstrate that neither is uniformly more efficient than the other. Numerical studies show that a smoothed bootstrap method works well for selecting the bandwidths in the smoothed nonparametric estimation. The use of the estimators is exemplified by an application to cumulative incidence and hazard of subtype-specific HIV infection from a sero-prevalence study in injecting drug users in Thailand. Copyright 2013, Oxford University Press.