Abstract
Initial investigation of patients with suspected SMM is the same used to diagnose symptomatic MM: CBC, creatinine, calcium, serum quantitative immunoglobulins, serum and urine protein electrophoresis, 24-h proteinuria, immunofixation in serum and urine, sFLC and their ratio [2]. Evaluation of PCs infiltration in either conventional bone marrow aspirate or biopsy is mandatory [6]. All patients should undergo whole-body MRI or PET/CT to discern active lesion if skeletal survey is negative [7]. FISH analysis is not mandatory, but it is highly recommended for all newly diagnosed patients [6].
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