Abstract
The role of smoking in the development of various diseases, including cardiovascular system is widely known and proven. At the same time, given the multi-component composition of tobacco smoke, many mechanisms of its damaging effect on the target organs remain unknown. Effect of smoking on duration of life and risk of cardiovascular diseases mediated by changes of rate of telomere shortening in chromosomes of eukaryotic cells has been actively studied in recent years. This article describes main damaging mechanisms of tobacco smoke on the cardiovascular system including changes at the molecular- genetic level.
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