Smoking Status is Associated with Serum High Molecular Adiponectin Levels in Community-Dwelling Japanese Men

Abstract

Serum high molecular weight (HMW) adiponectin improves insulin sensitivity, and a decreased level has been reported as a risk factor for the development of diabetes and coronary heart disease. This association may be further confounded by smoking, which is involved in the development of insulin resistance. The aim of this study was to determine whether smoking status is associated with serum HMW adiponectin levels in community-dwelling males. The cross-sectional study was carried out in 2002. Study participants without a clinical history of diabetes (724 men aged 60+/-14 (mean+/-standard deviation) (range, 20-89) years) were randomly recruited from a single community at an annual physical examination. They were classified into never-smokers, ex-smokers, light-smokers (<30 pack x year), and heavy-smokers (>or=30 pack x year). Mean serum HMW adiponectin levels were significantly lower in the current smokers than in the never- and ex-smokers but showed no significant difference between the light and heavy-smokers. Multiple linear regression analyses revealed that smoking status was significantly associated with HMW adiponectin levels, as were age, BMI, alcohol consumption, triglycerides, and high-density lipoprotein cholesterol. Multivariate-adjusted mean serum HMW adiponectin levels were lowest in the heavy-smokers, and significantly decreased in heavy-smokers compared with never-smokers and ex-smokers of an age >or=60 years, BMI >or=22 kg/m(2), alcohol consumption >or=22.9 g of ethanol/day, and HOMA-IR >or=1.6. Smoking status is associated with serum HMW adiponectin levels in community-dwelling Japanese men.