SMOKELESS TOBACCO;

Abstract

Objectives: To know the serum ferritin and vitamin B12 levels in relation to Creactive protein in individuals using smokeless tobacco in Hyderabad, sindh, Pakistan. StudyDesign: Cross sectional study. Place of Study: Private clinics of consultants of Hyderabad,Sindh, Pakistan. Duration of Study: January 2016 to February 2017. Methodology: Onehundred eighty three individuals were selected from different clinics of physicians, dentalsurgeons of sadder Hyderabad sindh Pakistan by judgmental sampling. Patients were youngsubjects, mean age was 21.4±7.4 years, mean BMI was 22.1±3.8 and mean duration ofchewing tobacco was 2±1.5 years. All types and forms of gutaka, manpuri and flavored betelnut were included like bombart, zafri and panparag. The dose was 30-100grams once or twotimes. SPSS 16 was used as statical software and Chai square test was used to calculatep value. P value was taken <0.05 statically significant. Results: Frequency of use of gutkawas 32%, Betel nut 38% and 29% had habit of chewing manpuri. Serum ferritin was low andc reactive protein was high, p value was <0.05 in gutaka and manpuri users. Vitamin B12was reduced significantly in gutaka user p value was <0.05. In betel nut chewers significantfinding was only high C reactive protein, p value <0.04. Conclusion: Smokeless tobacco hassignificant negative impact on serum ferritin and vitamin B12 levels. These chewing agents alsoincreased inflammatory markers like c reactive protein.