Abstract
Background Smokeless tobacco (SLT) as a drug substance has been used throughout the world although it has dangerous effects on human health. Among the 28 known carcinogens in SLT, tobacco-specific nitrosamines are considered to be the most potent. This has challenged the metabolic condition leading to a rise in the inflammatory status, increased apoptosis, and red blood cell (RBC) membrane damage. Therefore, the present study was undertaken to evaluate the adverse effects of SLT on hematological parameters and establish a correlation between them. Materials and Methods A total of 100 subjects (50 SLT users and 50 nonusers) were selected for the study. Complete demographic data and history were taken and clinical examination was done to evaluate any oral mucosal changes. Venous blood samples were taken to analyze the hematological parameters. Results Significant changes were observed in the complete blood profile in SLT users when compared to nonusers. All the hematological parameters had a negative correlation with form of SLT except for total leucocyte count which had a positive correlation. Conclusion The current study confers an imperative role into SLT mediated effects on a complete hemogram and might be beneficial in spreading awareness against its usage. It also serves as a forewarning alarm among the population consuming SLT as an alternative to smoking tobacco.
Highlights
Oral cancer, a modern epidemic among the noncommunicable diseases, is a major problem in the Indian subcontinent where it ranks among the top three types of cancer in the country. 20 per 100,000 individuals are affected by oral cancer accounting for about 30% of all types of cancer in the country
Healthy individuals with history of consumption of smokeless tobacco in any form and no history of any systemic illnesses were selected as Smokeless tobacco (SLT) users
SLT contains three to four times more nicotine than that delivered by a cigarette and it stays for a longer time in the bloodstream
Summary
A modern epidemic among the noncommunicable diseases, is a major problem in the Indian subcontinent where it ranks among the top three types of cancer in the country. 20 per 100,000 individuals are affected by oral cancer accounting for about 30% of all types of cancer in the country. Among the 28 known carcinogens in SLT, tobacco-specific nitrosamines are considered to be the most potent. This has challenged the metabolic condition leading to a rise in the inflammatory status, increased apoptosis, and red blood cell (RBC) membrane damage. The current study confers an imperative role into SLT mediated effects on a complete hemogram and might be beneficial in spreading awareness against its usage. It serves as a forewarning alarm among the population consuming SLT as an alternative to smoking tobacco
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