Abstract
The Smc5/6 protein complex inhibits the replication of hepatitis B virus (HBV) by an unknown mechanism. HBx, the regulatory protein of HBV, binds Smc5/6, promotes its ubiquitination by recruiting it to DDB1-CRL4 E3 ubiquitin ligase and mediates proteasomal degradation. In absence of HBx, Smc5/6 complex binds to cccDNA of HBV and inhibits transcription and replication of HBV. Thus Smc5/6 complex acts antagonistically to HBV infection. This could aid in the development of potential therapeutics against HBV infection. In this minireview, the role of Smc5/6 in replication and its interaction with HBx protein of HBV is discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
