Abstract
The current study aims for a simple, rapid, and smartphone‐based enhanced chemiluminescence (eCL) technique for sensitively detecting glucose in human urine. Herein, 1,3‐propanedithiol cross‐linked gold nanoparticles (GNPs‐PDT) via a simple reduction method is synthesized. Further, it is characterized by UV–vis spectroscopy and transmission electron microscopy. The synthesized GNPs‐PDT is found to possess oxidase mimetic activity and generate superoxide radicals from dissolved oxygen, which causes the oxidation of luminol to give a strong and stable CL signal. On the introduction of glucose into the reaction system, a CL quenching phenomenon is observed owing to the tendency of superoxide radicals to oxidize glucose into gluconic acid. Employing the quenching effect of glucose on the eCL signals, a sensor is designed for glucose detection in human urine samples. Under optimized conditions, the proposed method works in a dynamic range from 0.25 to 2 mM (R 2 = 0.98) with a detection limit of 0.36 mM. In addition, a simple and portable smartphone‐based imaging technique analyzed by Image J software for eCL‐based glucose sensing is proposed. The developed proof of concept provides good correlations of glucose detection in diabetic patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
