Abstract
Organoboron compounds have been playing an increasingly important role in analytical chemistry, material science, health applications, and particularly as functional polymers like boron carriers for cancer therapy. There are two main applications of boron isotopes in radiation cancer therapy, Boron Neutron Capture Therapy and Proton Boron Fusion Therapy. In this study, a novel and original material consisting of a three-dimensional polymer network crosslinked with ^{10}B enriched boric acid molecules is proposed and synthesized. The effects of the exposition to thermal neutrons were studied analyzing changes in the mechanical properties of the proposed material. Dedicated Monte Carlo simulations, based on MCNP and FLUKA main codes, were performed to characterize interactions of the proposed material with neutrons, photons, and charged particles typically present in mixed fields in nuclear reactor irradiations. Experimental results and Monte Carlo simulations were in agreement, thus justifying further studies of this promising material.
Highlights
Organoboron compounds have been playing an increasingly important role in analytical chemistry, material science, health applications, and as functional polymers like boron carriers for cancer therapy
The synthesis products consisted on a sponge-like solid and a liquid phase, it is well known that the structure of poly(HEMA) networks is highly dependent on the water content of the polymerization mixture, and monomeric Hydroxyethyl methacrylate (HEMA) is soluble in water, poly(HEMA) is not and has limited compatibility with the s olvent[41,42]
The implemented analytic technique used for measuring macroscopic mechanical properties needs to be further improved, the variations in the elastic modulus combined with the observed morphological changes support the potentiality of poly(HEMA)[10] B as a selective detector in mixed field irradiations
Summary
Organoboron compounds have been playing an increasingly important role in analytical chemistry, material science, health applications, and as functional polymers like boron carriers for cancer therapy. New trends in oncological radiation therapy are centered on the use of particles like neutrons or protons, rather than using high energy photon beams, mainly because of their precise energy deposition and minimum damage to healthy tissue[1,2] These novel treatments require a proper quality assurance to verify the prescribed treatment on patients and the design of new biocompatible materials that serve as carriers of markers, contrast or treatment enhancers[3,4]. Organoboron compounds have been playing an increasingly important role in analytical chemistry, organic synthesis and catalysis, drug delivery, material science, optoelectronic applications, and functional polymers used as boron carriers for cancer t herapy[14,15,16]. Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X (LIIFAMIRx), FAMAF-UNC, Córdoba X5000HUA, Argentina. 3Departamento de Química Orgánica, FCQ-UNC, Córdoba X5000HUA, Argentina. 4Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET, Córdoba X5000HUA, Argentina. 5Centro de Medicina Nuclear y Radioterapia Patagonia Austral (CEMNPA), Río Gallegos Z9400, Argentina. 6FCEFyN-UNC & CNEA-Reactor Nuclear RA-0, Córdoba X5000HUA, Argentina. 7Departamento de Bioquímica Clínica, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CONICET, FCQ-UNC, Córdoba X5000HUA, Argentina. 8Departamento de Ciencias Físicas, Centro de Física e Ingeniería en Medicina (CFIM), Universidad de La Frontera, Casilla 54‐D, Temuco, Chile. 9Present address: Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. 10These authors contributed : José Vedelago and Marcelo Romero. *email: mauro.valente@
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